Cardiology Digest Podcast: Episode #5

In this episode, we dive into the latest cardiovascular research into apixaban or warfarin, what is best for patients with an On-X mechanical aortic valve? Are popular home blood pressure devices validated? Which ambulatory blood pressure readings best predict mortality?

Franz Wiesbauer, MD MPH
Franz Wiesbauer, MD MPH
12th Jun 2023 • 2m read

Timestamped Show Overview

01:07 Potential accuracy of popular home blood pressure devices sold online
03:02 Ambulatory blood pressure and predicting mortality risk
05:17 Apixaban versus warfarin to prevent thromboembolic events in patients with mechanical heart valves

What are the latest cardiology studies?

STUDY #1:  
Dig into a study that issues a wake-up call about the potential accuracy of home blood pressure measurements. A dash of detective work is required here that could be the key to solving the mystery of some blood pressure anomalies. Cue suspenseful music!

"Approximately 80% of both arm and wrist devices were not validated... It's a good idea to ask patients to occasionally bring their home devices to the office so we can double-check their accuracy compared to our office devices."

Picone DS et al. Availability, cost, and consumer ratings of popular nonvalidated vs validated blood pressure–measuring devices sold online in 10 countries. JAMA 2023 May 2; 329:1514. (



Take a close look at 24-hour ambulatory blood pressure measurement and its prognostic value. This is a robust study, but doesn't shy away from addressing some thorny issues surrounding the use of ambulatory monitoring in the U.S. Does this comprehensive blood pressure monitoring lead to better clinical outcomes? This is sure to spark some debate!

"Nighttime ambulatory blood pressure was about six times more informative for the risk of death than clinic blood pressure."

 "Variable insurance coverage, and variable acceptability to patients can be barriers to the use of ambulatory monitoring in the U.S."

Staplin N et al. Relationship between clinic and ambulatory blood pressure and mortality: An observational cohort study in 59 124 patients. Lancet 2023 May 5; [e-pub]. (



Explore a paper that evaluates whether apixaban, a commonly prescribed oral anticoagulant, had a higher rate of thromboembolic events than warfarin when given to patients with On-X mechanical aortic valves. Tune in as we explore the implications of this eye-opening research!

"Despite the benefits of oral anticoagulants like apixaban in patients with atrial fibrillation, this study adds to others that have shown direct oral anticoagulants should not be prescribed for patients with mechanical heart valves."

Wang TY et al. Apixaban or warfarin in patients with an On-X mechanical aortic valve. NEJM Evid 2023 May 6; [e-pub]. (


Join us for this informative overview of contemporary research, as we break down complex medical concepts into digestible nuggets of knowledge, suitable for both medical students and healthcare professionals eager to keep up-to-date in cardiology.

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