Infectious diseases

Malaria Clinical Guide

Malaria is a disease which affects approximately 100 million people and kills several hundred thousand each year. In our era of world travel, most primary care physicians and many specialists are bound to encounter patients who have travelled from or are planning to travel to regions of the planet where malaria is prevalent. So odds are high that you will see this disease in your practice.

In this Clinical Guide, we summarize the essential knowledge you need to diagnose and treat your patients with malaria.


11 Articles | Guide last updated - 3rd Jul 2020

Malaria transmission and infection

In the articles of this chapter, we review the various species of Plasmodium as well as their geography and the severity of infection they cause. We summarize the sexual and asexual life cycles of the parasite, as well as how the various species invade young, normal, or aging red blood cells and use hemoglobin to propagate. Lastly, we review various genetic and environmental factors that affect malaria infection, morbidity, and mortality.

Malaria diagnosis and treatment

In the articles of this chapter, we dive deeper into the clinical manifestations of the various types of malaria and show you pathologically why Plasmodium kills thousands of vulnerable individuals each year. We’ll prepare you to begin to develop confidence in screening blood films for these parasites based upon morphologic features of the different species. We review how anti-malarial drugs work and the rationale for their use in both milder cases of malaria as well as severe, life-threatening cases. Lastly, we summarize the current and future species-specific prevention strategies.