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you!",{"id":215,"name":216},1,"Course previews",[218,229,234],{"type":219,"data":220},"video",{"readDurationInSeconds":221,"video":222},115,{"platform":223,"name":224,"url":225,"size":226},"YouTube","Understanding thryroid hormone production","https:\u002F\u002Fwww.youtube.com\u002Fwatch?v=dRaSZvD-Ku8",{"width":227,"height":228},200,113,{"type":230,"data":231},"free_text",{"readDurationInSeconds":232,"text":233},9.866666666666667,"\u003Cp>\u003C!--td {border: 1px solid #ccc;}br {mso-data-placement:same-cell;}-->This video from our \u003Ca href=\"https:\u002F\u002Fapp.medmastery.com\u002Fcourses\u002F3749\">Thyroid Disease Masterclass\u003C\u002Fa> is a fast-paced refresher on how T3 and T4 are produced. Find out how they differ from each other and the exact steps taken by the thyroid follicles to convert iodine into these two essential hormones.\u003C\u002Fp>",{"type":230,"data":235},{"readDurationInSeconds":236,"title":237,"text":238},45.86666666666667,"Video Transcript","\u003Cp dir=\"ltr\">\u003Cb id=\"docs-internal-guid-4a871abf-7fff-00ba-0798-356d539424e3\">[00:00:00]\u003C\u002Fb> Thyroid hormone is produced in two forms: T3, which is the active form of thyroid hormone and T4, which is an inactive precursor to T3. Most of the thyroid hormone that's produced by the thyroid, about 80% is present as T4 and only 20% is secreted as T3. T4 travels to the target tissues through the bloodstream, where it's converted to active T3. Thyroid hormone requires iodine for its production, as iodine is a key structural component of the \u003C\u002Fp>\u003Cp dir=\"ltr\">\u003Cb id=\"docs-internal-guid-4a871abf-7fff-00ba-0798-356d539424e3\">[00:00:30] \u003C\u002Fb>thyroid hormone. T3 consists of three iodines, whereas T4 consists of four iodines. Thyroid hormone synthesis occurs at the follicular cell, in the colloid in the follicles of the thyroid. This involves several steps, which we will review in the next few slides. The first step of thyroid hormone synthesis is iodine uptake. Iodine from the bloodstream is transported into the cells, via sodium iodine symporter and the iodine is then transported into the colloid. In the colloid, \u003C\u002Fp>\u003Cp dir=\"ltr\">\u003Cb id=\"docs-internal-guid-4a871abf-7fff-00ba-0798-356d539424e3\">[00:01:00] \u003C\u002Fb>an enzyme called thyroid peroxidase or TPO, oxidizes the iodine and then catalyzes its binding to a protein called thyroglobulin. Upon binding to thyroglobulin, the iodine forms thyroid hormone precursors: DIT and MIT. These precursors are coupled together to form T4 and T3. T3 and T4 are then taken up by the cell, dissociated from the thyroglobulin molecule, and secreted into the bloodstream, \u003C\u002Fp>\u003Cp dir=\"ltr\">\u003Cb id=\"docs-internal-guid-4a871abf-7fff-00ba-0798-356d539424e3\">[00:01:30] \u003C\u002Fb>where they travel to the target tissue.\u003C\u002Fp>",{"courses":240,"showAwardsBelow":48},[241],{"id":242,"isFreeCmeCourse":243,"title":244,"type":245,"specialization":246,"teachers":248,"cmeCredits":250,"teacherIllustration":251,"backgroundImage":252,"relativeUrl":253,"lastChanged":254,"created":255,"description":256,"relativeURL":253,"meta":257},3749,false,"Thyroid Disease Masterclass","course",[247],"Endocrinology",[249],"Tracy Tylee, MD",3,"https:\u002F\u002Fmedmastery-backend-prod-kjbeds.s3.eu-west-1.amazonaws.com\u002Fmedia\u002Fimages\u002F99f55f0f-1e9c-413b-a826-11c1e0ec9808","https:\u002F\u002Fmedmastery-backend-prod-kjbeds.s3.eu-west-1.amazonaws.com\u002Fmedia\u002Fimages\u002F99f55f0f-e1ca-46d7-9d36-ce0e3d322f8b","\u002Fcourses\u002Fthyroid-disease-masterclass","1767867649","1499852541","Using simple illustrations and elegant animations, we review the pathophysiology of thyroid dysfunction, discuss the interpretation of thyroid tests, explain how pregnancy and certain medications can alter thyroid function, and evaluate the best treatment options—this course will prepare you to confidently assess and effectively manage patients with thyroid disease.",{"duration":258,"quizzes":259,"lessons":260},5383,9,56,{"id":262,"name":249,"image":263,"profession":264,"relativeUrl":267,"specializations":268},3748,"https:\u002F\u002Fmedmastery-backend-prod-kjbeds.s3.eu-west-1.amazonaws.com\u002Fmedia\u002Fimages\u002F9c43cefc-88e6-4632-a711-cf90c6d98c24",{"name":265,"description":266},"Endocrinologist","Tracy is an Associate Professor of Endocrinology at the University of Washington, and Program Director for the Endocrinology Fellowship Program.","\u002Fteachers\u002Ftracy-tylee-md",[247],62,"2m",[272,300,319],{"id":273,"title":274,"text":275,"image":276,"author":284,"path":293,"readDuration":294,"readDurationFormatted":295,"internal":296},1350,"How to recognize INOCA (ANOCA) on an exercise stress test ","Angina, abnormal stress test, clean coronaries—that's INOCA (or ANOCA), and it carries real risk. 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Learn how to treat mild and moderate COPD exacerbations—and when to escalate care.",{"alt":324,"title":278,"size":325,"location":326},"Older patient using a handheld nebulizer to inhale bronchodilator medication during an acute COPD exacerbation",{"width":307,"height":307},{"bucket":282,"key":327},"\u002F2026-04\u002FC133(4)_ exacerbations_magazine image.png",{"id":329,"title":330,"relativeURL":331,"image":332,"professionLong":333,"profession":334,"weight":336},5365,"Siamak Moayedi, MD","\u002Fteachers\u002Fsiamak-moayedi-md","https:\u002F\u002Fmedmastery-backend-prod-kjbeds.s3.eu-west-1.amazonaws.com\u002Fmedia\u002Fimages\u002F9c43cf02-1064-4074-817b-0eb5de6ded74","Professor and Director of Medical Student Education, University of Maryland and Course Director, Essential and Critical Procedures, Emergency Medicine.",{"name":335},"Emergency medicine physician",1533,"\u002Fmagazine\u002Facute-copd-exacerbation-treatment",191,"4m",{"created":341,"updated":342,"published":343},1776705362,1776710540,1776710541,{"seo":345,"og":347},{"title":346,"description":213},"Understanding thyroid hormone production | Medmastery",{"title":346,"description":213,"image":348},{"alt":278,"title":278,"size":349,"location":352},{"width":350,"height":351},480,327,{"bucket":282,"key":353},"\u002Fmigrated-images\u002F170725_2-magazine.jpg",{"id":355,"created":356,"updated":357,"published":356},127,1500979694,1736534561]