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enseignants",{"title":54,"url":55},{"title":57,"url":58},{"title":186,"group":48,"menu":187},"Produit",[188,189,190,191,192,193,194],{"title":38,"url":7},{"title":65,"url":66},{"title":68,"url":69},{"title":71,"url":72},{"title":74,"url":75},{"title":15,"url":77},{"title":195,"url":10},"Tarification",{"title":197,"group":48,"menu":198},"Mentions légales",[199,200,201,202,203],{"title":197,"url":84},{"title":86,"url":87},{"title":89,"url":90},{"title":92,"url":93},{"title":95,"url":96},{"title":205,"group":48,"menu":206},"Service client",[207,208,209],{"title":101,"url":102},{"title":104,"url":105},{"title":107,"url":108},{"content":211,"related":283,"meta":350,"internal":360},{"title":212,"leadIn":213,"category":214,"elements":217,"becomeAnExpert":252,"author":273,"readDuration":281,"readDurationFormatted":282},"How to interpret total thyroid hormone levels","In this video, you'll learn the nuts and bolts of how to interpret total thyroid hormone levels.",{"id":215,"name":216},1,"Course previews",[218,229,234,239,247],{"type":219,"data":220},"video",{"readDurationInSeconds":221,"video":222},153,{"platform":223,"name":224,"url":225,"size":226},"YouTube","Evaluating total thyroid hormone levels","https:\u002F\u002Fwww.youtube.com\u002Fwatch?v=WqkAU-YmvSU",{"width":227,"height":228},200,113,{"type":230,"data":231},"free_text",{"readDurationInSeconds":232,"text":233},12.533333333333333,"\u003Cp>Total thyroid hormone levels are not physiologically active in our bodies, but T3 and free thyroid hormone levels are. In this video from our \u003Ca href=\"https:\u002F\u002Fapp.medmastery.com\u002Fcourses\u002F3749\">Thyroid Disease Masterclass\u003C\u002Fa>, you’ll learn the nuts and bolts of how to interpret total thyroid hormone levels and why this figure does not provide an accurate reflection of thryroid function.\u003C\u002Fp>",{"type":230,"data":235},{"readDurationInSeconds":236,"title":237,"text":238},13.866666666666665,"Join our Thyroid Disease Masterclass now!","\u003Cp>Using simple illustrations and elegant animations we review the pathophysiology of thyroid dysfunction, discuss the interpretation of thyroid tests, explain how pregnancy and certain medications can alter thyroid function, and evaluate the best treatment options—this \u003Ca href=\"https:\u002F\u002Fapp.medmastery.com\u002Fcourses\u002F3749\">course\u003C\u002Fa> will prepare you to confidently assess and effectively manage patients with thyroid disease.\u003C\u002Fp>",{"type":240,"data":241},"cta",{"readDurationInSeconds":242,"text":243,"buttonText":244,"buttonUrl":245,"teachIllustration":246},3.7333333333333334,"Start the first chapter of our Thyroid Disease Masterclass course for free","Start chapter 1 now","https:\u002F\u002Fwww.medmastery.com\u002Fuser\u002Fregister?target=%2Fcourses%2Fthyroid-disease-masterclass","https:\u002F\u002Fmedmastery-backend-prod-kjbeds.s3.eu-west-1.amazonaws.com\u002Fmedia\u002Fimages\u002F99f55f0f-1e9c-413b-a826-11c1e0ec9808",{"type":230,"data":248},{"readDurationInSeconds":249,"title":250,"text":251},73.6,"Video Transcript","\u003Cp dir=\"ltr\">\u003Cb id=\"docs-internal-guid-e390097c-7fff-08b9-4b98-27da3dd0e9e3\">[00:00:00] \u003C\u002Fb>Most of the thyroid hormone that's present in circulation is bound to protein. Less than one-tenth of 1% of circulating thyroid hormone is free or active. When we measure total thyroid hormone, we're measuring both the bound thyroid hormone as well as the free thyroid hormone. Most assays for measuring total thyroid hormone are competitive immunoassays. In these assays, we have a radiolabeled thyroid hormone analog that's bound \u003C\u002Fp>\u003Cp dir=\"ltr\">\u003Cb id=\"docs-internal-guid-e390097c-7fff-08b9-4b98-27da3dd0e9e3\">[00:00:30] \u003C\u002Fb>to an antibody-coated plate. The patient sample is added and the patient's thyroid hormone will displace the radiolabeled analogs. The sample is then washed and the displaced analog is rinsed away, leaving the bound analog to be measured. So, let's look at a few examples of how this works for our patients. So, let's say we have a patient with high thyroid hormone levels. This thyroid hormone is going to displace most of the bound analog, which is then going to be rinsed away leaving \u003C\u002Fp>\u003Cp dir=\"ltr\">\u003Cb id=\"docs-internal-guid-e390097c-7fff-08b9-4b98-27da3dd0e9e3\">[00:01:00] \u003C\u002Fb>very low signal. Conversely, a patient with low thyroid hormone levels will only displace a few of the radiolabeled analogs. Those will be washed away, leaving a high signal. This signal is measured and from that result, we're able to calculate the amount of total thyroid hormone that was present in the original sample and that is the result that is reported out to you. T3 and T4 are both present in circulation and both can be measured using total thyroid hormone assays. However, T3 \u003C\u002Fp>\u003Cp dir=\"ltr\">\u003Cb id=\"docs-internal-guid-e390097c-7fff-08b9-4b98-27da3dd0e9e3\">[00:01:30] \u003C\u002Fb>is present at 5 to 10 fold lower levels than T4 so measuring this is more technically challenging. While total thyroid hormone assays are usually a fairly good reflection of the amount of free or active thyroid hormone present in the circulation, there are some situations where they are not accurate. Sometimes, the amount of bound thyroid hormone will be higher but the amount of free thyroid hormone will remain the same. So, in that case, you would have an increase in your total \u003C\u002Fp>\u003Cp dir=\"ltr\">\u003Cb id=\"docs-internal-guid-e390097c-7fff-08b9-4b98-27da3dd0e9e3\">[00:02:00]\u003C\u002Fb> thyroid hormone level but your active thyroid hormone levels would remain unchanged. So, total thyroid hormone assays are rarely used as stand-alone measurements of thyroid function\u003C\u002Fp>",{"courses":253,"showAwardsBelow":48},[254],{"id":255,"isFreeCmeCourse":256,"title":257,"type":258,"specialization":259,"teachers":261,"cmeCredits":263,"teacherIllustration":246,"backgroundImage":264,"relativeUrl":265,"lastChanged":266,"created":267,"description":268,"relativeURL":265,"meta":269},3749,false,"Thyroid Disease Masterclass","course",[260],"Endocrinology",[262],"Tracy Tylee, MD",3,"https:\u002F\u002Fmedmastery-backend-prod-kjbeds.s3.eu-west-1.amazonaws.com\u002Fmedia\u002Fimages\u002F99f55f0f-e1ca-46d7-9d36-ce0e3d322f8b","\u002Fcourses\u002Fthyroid-disease-masterclass","1767867649","1499852541","Using simple illustrations and elegant animations, we review the pathophysiology of thyroid dysfunction, discuss the interpretation of thyroid tests, explain how pregnancy and certain medications can alter thyroid function, and evaluate the best treatment options—this course will prepare you to confidently assess and effectively manage patients with thyroid disease.",{"duration":270,"quizzes":271,"lessons":272},5383,9,56,{"id":274,"name":262,"image":275,"profession":276,"relativeUrl":279,"specializations":280},3748,"https:\u002F\u002Fmedmastery-backend-prod-kjbeds.s3.eu-west-1.amazonaws.com\u002Fmedia\u002Fimages\u002F9c43cefc-88e6-4632-a711-cf90c6d98c24",{"name":277,"description":278},"Endocrinologist","Tracy is an Associate Professor of Endocrinology at the University of Washington, and Program Director for the Endocrinology Fellowship Program.","\u002Fteachers\u002Ftracy-tylee-md",[260],110,"2m",[284,312,331],{"id":285,"title":286,"text":287,"image":288,"author":296,"path":305,"readDuration":306,"readDurationFormatted":307,"internal":308},1351,"Starting statins as first-line therapy for hyperlipidemia","Starting statins: how to choose the right agent for your patient, match statin intensity to cardiovascular risk, and monitor effectively after initiation.",{"alt":289,"title":290,"size":291,"location":293},"Healthcare provider discussing starting statins with a patient and reviewing a medication bottle","",{"width":292,"height":292},660,{"bucket":294,"key":295},"public-drupal-medmastery-assets-production","\u002F2026-05\u002FC121(2)_magazine image.png",{"id":297,"title":298,"relativeURL":299,"image":300,"professionLong":301,"profession":302,"weight":304},1563,"Franz Wiesbauer, MD MPH","\u002Fteachers\u002Ffranz-wiesbauer-md-mph","https:\u002F\u002Fmedmastery-backend-prod-kjbeds.s3.eu-west-1.amazonaws.com\u002Fmedia\u002Fimages\u002F9c43cef0-41ee-4005-9e4a-d8711c816401","Franz is the founder and CEO of Medmastery. He is an internist with a specialization in cardiology and a master’s in public health from Johns Hopkins University.",{"name":303},"Internist",4,"\u002Fmagazine\u002Fstarting-statins-first-line-therapy",238,"4m",{"created":309,"updated":310,"published":311},1778960150,1779196374,1778961827,{"id":313,"title":314,"text":315,"image":316,"author":322,"path":324,"readDuration":325,"readDurationFormatted":326,"internal":327},1350,"How to recognize INOCA (ANOCA) on an exercise stress test ","Angina, abnormal stress test, clean coronaries—that's INOCA (or ANOCA), and it carries real risk. Learn to recognize and report it with exercise stress ECG.",{"alt":317,"title":290,"size":318,"location":320},"Illustration of the heart's coronary vasculature showing large coronary arteries and the extensive network of smaller vessels affected in INOCA (ischemia with nonobstructive coronary arteries).",{"width":319,"height":319},1200,{"bucket":294,"key":321},"\u002F2026-05\u002FC17(1)_magazine image_0.png",{"id":297,"title":298,"relativeURL":299,"image":300,"professionLong":301,"profession":323,"weight":304},{"name":303},"\u002Fmagazine\u002Fexercise-stress-ecg-inoca",141,"3m",{"created":328,"updated":329,"published":330},1778115738,1778799792,1778118255,{"id":332,"title":333,"text":334,"image":335,"author":341,"path":343,"readDuration":344,"readDurationFormatted":345,"internal":346},1348,"Hyperlipidemia screening: who, when, & what to measure","Testing for hyperlipidemia can help you mitigate your patients' cardiovascular risk. Learn who to screen and when, which measures to request, and how to stratify risk.",{"alt":336,"title":290,"size":337,"location":339},"Lipid panel blood sample tubes used to test for hyperlipidemia in a laboratory setting",{"width":338,"height":338},600,{"bucket":294,"key":340},"\u002F2026-04\u002FC121_magazine image.png",{"id":297,"title":298,"relativeURL":299,"image":300,"professionLong":301,"profession":342,"weight":304},{"name":303},"\u002Fmagazine\u002Ftest-for-hyperlipidemia",246,"5m",{"created":347,"updated":348,"published":349},1777403036,1777572381,1777412421,{"seo":351,"og":353},{"title":352,"description":213},"How to interpret total thyroid hormone levels | Medmastery",{"title":352,"description":213,"image":354},{"alt":290,"title":290,"size":355,"location":358},{"width":356,"height":357},480,333,{"bucket":294,"key":359},"\u002Fmigrated-images\u002F170726-magazine.jpg",{"id":361,"created":362,"updated":363,"published":362},128,1501140753,1736534668]