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previews",[218,228,233,238,245],{"type":219,"data":220},"video",{"readDurationInSeconds":221,"video":222},149,{"platform":223,"name":212,"url":224,"size":225},"YouTube","https:\u002F\u002Fwww.youtube.com\u002Fwatch?v=9d-DJNfip_Y",{"width":226,"height":227},200,113,{"type":229,"data":230},"free_text",{"readDurationInSeconds":231,"text":232},14.133333333333333,"\u003Cp>Learn how to pinpoint the cause of prolonged PTT and investigate bleeding in patients with normal PTT. In this video, from our Hematology and Coagulation Essentials course, you'll learn all about the mechanisms behind PTT tests and how to interpret the results. You will be able to formulate a common differential diagnosis for prolonged PTT and know which tests to order next.\u003C\u002Fp>",{"type":229,"data":234},{"readDurationInSeconds":235,"title":236,"text":237},18.933333333333334,"Join our Hematology and Coagulation Essentials course today!","\u003Cp>Demystify hematology and coagulation with our fascinating \u003Cstrong>\u003Ca href=\"https:\u002F\u002Fwww.medmastery.com\u002Fcourse\u002Fhematology-and-coagulation-essentials\">Hematology & Coagulation Essentials\u003C\u002Fa> \u003C\u002Fstrong>course. Hematological and coagulation disorders can be difficult to diagnose. By the end of this course, you'll be able to confidently assess the most important diagnostic aspects of hematology and coagulation and shine during your next night on call! Never again will you wonder what a prolonged PTT really means, how to differentiate between a factor deficiency and an inhibitor, or what tests to order next.\u003C\u002Fp>",{"type":239,"data":240},"cta",{"readDurationInSeconds":241,"text":242,"buttonText":243,"buttonUrl":244},3.466666666666667,"Become a great clinician with our video courses and workshops","Start learning for free","https:\u002F\u002Fwww.medmastery.com\u002Fuser\u002Fregister",{"type":229,"data":246},{"readDurationInSeconds":247,"title":248,"text":249},54.666666666666664,"Video Transcript","\u003Cp dir=\"ltr\">\u003Cstrong>[00:00:00]\u003C\u002Fstrong> Here we're going to discuss the partial thromboplastin time or PTT. PTT is a test to measure the integrity of the intrinsic and the common pathway. To measure PTT, blood is collected in a citrate tube. Patient's platelet-poor plasma is mixed with a surface activating agent such as silica or kaolin and platelet substitute such as crude phospholipid is added. Clotting time is measured and the normal PTT is up to approximately \u003C\u002Fp>\u003Cp dir=\"ltr\">\u003Cstrong>[00:00:30]\u003C\u002Fstrong> 35 seconds. PTT measures the integrity of the intrinsic and the common pathway. The PT is a test for the integrity of the extrinsic and the common pathway. If an individual has isolated prolonged partial thromboplastin time, then the defect is in the intrinsic pathway. Within the intrinsic pathway, are factors 12, 11, 9, and 8, therefore, causes of an \u003C\u002Fp>\u003Cp dir=\"ltr\">\u003Cstrong>[00:01:00]\u003C\u002Fstrong> isolated prolonged partial thromboplastin time should be due to deficiency or inhibitors of these clotting factors. However, please know that if an individual has abnormality of factor 12, the patient does not develop any bleeding. If levels of factor 8, 9, 11 are reduced and this condition is inherited, these are known as hemophilia A, B, and C respectively. There are\u003C\u002Fp>\u003Cp dir=\"ltr\">\u003Cstrong>[00:01:30] \u003C\u002Fstrong>some other causes of isolated prolonged partial thromboplastin time and these include inhibitors to factor 8, 9, and 11, Von Willebrand's disease, the drug heparin, and lupus anticoagulant. Patients with von Willebrand disease have low levels of factor 8. Heparin and lupus anticoagulant acts against multiple clotting factors, thus, prolonging PTT. When faced with a prolonged PTT, what should \u003C\u002Fp>\u003Cp dir=\"ltr\">\u003Cstrong>[00:02:00]\u003C\u002Fstrong> we do next? The next test to order is a mixing study, which will be discussed again in another lesson.\u003C\u002Fp>",{"courses":251,"showAwardsBelow":48},[252],{"id":253,"isFreeCmeCourse":254,"title":255,"type":256,"specialization":257,"teachers":259,"cmeCredits":261,"teacherIllustration":262,"backgroundImage":263,"relativeUrl":264,"lastChanged":265,"created":266,"description":267,"relativeURL":264,"meta":268},4772,false,"Hematology and Coagulation Essentials","course",[258],"Hematology",[260],"Md. Amer Wahed, MD FRCPath",6,"https:\u002F\u002Fmedmastery-backend-prod-kjbeds.s3.eu-west-1.amazonaws.com\u002Fmedia\u002Fimages\u002F99f55ed7-3151-4bb7-9c69-aeb2bf3b92be","https:\u002F\u002Fmedmastery-backend-prod-kjbeds.s3.eu-west-1.amazonaws.com\u002Fmedia\u002Fimages\u002F99f55ed7-e6a5-4247-b5c3-e54070339955","\u002Fcourses\u002Fhematology-and-coagulation-essentials","1777141804","1524670658","Hematological and coagulation disorders can be hard to diagnose. 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Learn who to screen and when, which measures to request, and how to stratify risk.",{"alt":319,"title":292,"size":320,"location":322},"Lipid panel blood sample tubes used to test for hyperlipidemia in a laboratory setting",{"width":321,"height":321},600,{"bucket":296,"key":323},"\u002F2026-04\u002FC121_magazine image.png",{"id":299,"title":300,"relativeURL":301,"image":302,"professionLong":303,"profession":325,"weight":306},{"name":305},"\u002Fmagazine\u002Ftest-for-hyperlipidemia",246,"5m",{"created":330,"updated":331,"published":332},1777403036,1777572381,1777412421,{"id":334,"title":335,"text":336,"image":337,"author":342,"path":351,"readDuration":352,"readDurationFormatted":353,"internal":354},1347,"Outpatient care for COPD exacerbations","Most acute COPD exacerbations can be managed with outpatient treatment. Learn how to treat mild and moderate COPD exacerbations—and when to escalate care.",{"alt":338,"title":292,"size":339,"location":340},"Older patient using a handheld nebulizer to inhale bronchodilator medication during an acute COPD exacerbation",{"width":321,"height":321},{"bucket":296,"key":341},"\u002F2026-04\u002FC133(4)_ exacerbations_magazine image.png",{"id":343,"title":344,"relativeURL":345,"image":346,"professionLong":347,"profession":348,"weight":350},5365,"Siamak Moayedi, MD","\u002Fteachers\u002Fsiamak-moayedi-md","https:\u002F\u002Fmedmastery-backend-prod-kjbeds.s3.eu-west-1.amazonaws.com\u002Fmedia\u002Fimages\u002F9c43cf02-1064-4074-817b-0eb5de6ded74","Professor and Director of Medical Student Education, University of Maryland and Course Director, Essential and Critical Procedures, Emergency Medicine.",{"name":349},"Emergency medicine physician",1533,"\u002Fmagazine\u002Facute-copd-exacerbation-treatment",191,"4m",{"created":355,"updated":356,"published":357},1776705362,1776710540,1776710541,{"seo":359,"og":361},{"title":360,"description":213},"How to interpret a partial thromboplastin time (PTT) test | Medmastery",{"title":360,"description":213,"image":362},{"alt":292,"title":292,"size":363,"location":366},{"width":364,"height":365},1270,654,{"bucket":296,"key":367},"\u002Fmigrated-images\u002FScreen Shot 2018-05-30 at 11.07.38 am.png",{"id":369,"created":370,"updated":371,"published":370},221,1531992959,1655189586]