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previews",[218,229,234,238,245],{"type":219,"data":220},"video",{"readDurationInSeconds":221,"video":222},0,{"platform":223,"name":224,"url":225,"size":226},"YouTube","Minimizing weight gain","https:\u002F\u002Fwww.youtube.com\u002Fwatch?v=VNimv2Syw2o",{"width":227,"height":228},200,113,{"type":230,"data":231},"free_text",{"readDurationInSeconds":232,"text":233},10.933333333333334,"\u003Cp>One of the most daunting parts of managing patients with diabetes is preventing the weight gain that comes along with certain therapies. In this video, from our \u003Ca href=\"https:\u002F\u002Fwww.medmastery.com\u002Fcourse\u002Fdiabetes-mellitus-masterclass\">Diabetes Mellitus Masterclass\u003C\u002Fa> course, you'll learn how to select a diabetes regimen that results in minimal weight gain for your patients.\u003C\u002Fp>",{"type":230,"data":235},{"readDurationInSeconds":232,"title":236,"text":237},"Join our Diabetes Mellitus Masterclass course today!","\u003Cp>Learn how to confidently manage diabetes with our \u003Ca href=\"https:\u002F\u002Fwww.medmastery.com\u002Fcourse\u002Fdiabetes-mellitus-masterclass\">Diabetes Mellitus Masterclass\u003C\u002Fa> course. You'll discover how to fine-tune your patients' treatment plans, initiate, adjust, and manage insulin regimes, and screen for diabetic complications with total ease!\u003C\u002Fp>",{"type":239,"data":240},"cta",{"readDurationInSeconds":241,"text":242,"buttonText":243,"buttonUrl":244},3.466666666666667,"Become a great clinician with our video courses and workshops","Start learning for free","https:\u002F\u002Fwww.medmastery.com\u002Fuser\u002Fregister",{"type":230,"data":246},{"readDurationInSeconds":247,"title":248,"text":249},87.73333333333333,"Video Transcript","\u003Cp dir=\"ltr\">\u003Cstrong>[00:00:00]\u003C\u002Fstrong> A primary concern for many patients with type 2 diabetes is weight gain. Unfortunately, weight gain is a common side effect for many of our diabetes medications. So, when looking at different medication options for your patients, you'll often want to consider the risk of weight gain and select medications that minimize this or may even aid in weight loss. Again, metformin is going to be your first choice for nearly all patients with\u003C\u002Fp>\u003Cp dir=\"ltr\">\u003Cstrong>[00:00:30]\u003C\u002Fstrong> type 2 diabetes, including those concerned with weight. It's considered weight neutral and may actually cause weight loss in some patients. For patients concerned with weight gain, lifestyle intervention is important to emphasize as well. As with all patients with type 2 diabetes, you want to reassess glycemic control after three months of therapy. If glucose goals are not met after three months of metformin, we need to add a second medication. If you're looking to minimize weight gain, the best options are the DPP-4\u003C\u002Fp>\u003Cp dir=\"ltr\">\u003Cstrong>[00:01:00]\u003C\u002Fstrong> inhibitors, the SGLT-2 inhibitors or the GLP-1 receptor agonists. The DPP-4 inhibitors are weight neutral so will limit weight gain but often patients concerned with weight, up for medication that can cause weight loss, either the GLP-1 receptor agonists or the SGLT-2 inhibitors. In this case, I will generally choose the GLP-1 receptor agonists for patients who are okay with injections or the SGLT-2 inhibitors for patients who would prefer an oral medication. \u003C\u002Fp>\u003Cp dir=\"ltr\">\u003Cstrong>[00:01:30]\u003C\u002Fstrong> The primary side effect with the GLP-1 receptor agonists is nausea, while the SGLT-2 inhibitors can cause increased urination, vaginal yeast infections or urinary tract infections, which can be bothersome for some patients. The DPP-4 inhibitors are generally well tolerated but not as effective as the other two medications. If blood sugars aren't at goal three months after introducing the second medication, the third step of the treatment algorithm is further \u003C\u002Fp>\u003Cp dir=\"ltr\">\u003Cstrong>[00:02:00]\u003C\u002Fstrong> intensification with a third agent. Again, for patients whose primary goal is minimizing weight gain, you will want to choose either an incretin or an SGLT-2 inhibitor. These medications work well in combination due to their different actions to lower blood sugars. If your patient cannot achieve their A1c goals on three non-insulin agents, you will need to consider starting insulin. Unfortunately, nearly all patients will gain weight on insulin but with \u003C\u002Fp>\u003Cp dir=\"ltr\">\u003Cstrong>[00:02:30] \u003C\u002Fstrong>continued efforts at diet and lifestyle, you can minimize this while improving glucose control.\u003C\u002Fp>",null,{"id":252,"name":253,"image":254,"profession":255,"relativeUrl":258,"specializations":259},3748,"Tracy Tylee, MD","https:\u002F\u002Fmedmastery-backend-prod-kjbeds.s3.eu-west-1.amazonaws.com\u002Fmedia\u002Fimages\u002F9c43cefc-88e6-4632-a711-cf90c6d98c24",{"name":256,"description":257},"Endocrinologist","Tracy is an Associate Professor of Endocrinology at the University of Washington, and Program Director for the Endocrinology Fellowship Program.","\u002Fteachers\u002Ftracy-tylee-md",[260],"Endocrinology",119,"2m",[264,292,311],{"id":265,"title":266,"text":267,"image":268,"author":276,"path":285,"readDuration":286,"readDurationFormatted":287,"internal":288},1351,"Starting statins as first-line therapy for hyperlipidemia","Starting statins: how to choose the right agent for your patient, match statin intensity to cardiovascular risk, and monitor effectively after initiation.",{"alt":269,"title":270,"size":271,"location":273},"Healthcare provider discussing starting statins with a patient and reviewing a medication bottle","",{"width":272,"height":272},660,{"bucket":274,"key":275},"public-drupal-medmastery-assets-production","\u002F2026-05\u002FC121(2)_magazine image.png",{"id":277,"title":278,"relativeURL":279,"image":280,"professionLong":281,"profession":282,"weight":284},1563,"Franz Wiesbauer, MD MPH","\u002Fteachers\u002Ffranz-wiesbauer-md-mph","https:\u002F\u002Fmedmastery-backend-prod-kjbeds.s3.eu-west-1.amazonaws.com\u002Fmedia\u002Fimages\u002F9c43cef0-41ee-4005-9e4a-d8711c816401","Franz is the founder and CEO of Medmastery. He is an internist with a specialization in cardiology and a master’s in public health from Johns Hopkins University.",{"name":283},"Internist",4,"\u002Fmagazine\u002Fstarting-statins-first-line-therapy",238,"4m",{"created":289,"updated":290,"published":291},1778960150,1778962081,1778961827,{"id":293,"title":294,"text":295,"image":296,"author":302,"path":304,"readDuration":305,"readDurationFormatted":306,"internal":307},1350,"How to recognize INOCA (ANOCA) on an exercise stress test ","Angina, abnormal stress test, clean coronaries—that's INOCA (or ANOCA), and it carries real risk. Learn to recognize and report it with exercise stress ECG.",{"alt":297,"title":270,"size":298,"location":300},"Illustration of the heart's coronary vasculature showing large coronary arteries and the extensive network of smaller vessels affected in INOCA (ischemia with nonobstructive coronary arteries).",{"width":299,"height":299},1200,{"bucket":274,"key":301},"\u002F2026-05\u002FC17(1)_magazine image_0.png",{"id":277,"title":278,"relativeURL":279,"image":280,"professionLong":281,"profession":303,"weight":284},{"name":283},"\u002Fmagazine\u002Fexercise-stress-ecg-inoca",141,"3m",{"created":308,"updated":309,"published":310},1778115738,1778799792,1778118255,{"id":312,"title":313,"text":314,"image":315,"author":321,"path":323,"readDuration":324,"readDurationFormatted":325,"internal":326},1348,"Hyperlipidemia screening: who, when, & what to measure","Testing for hyperlipidemia can help you mitigate your patients' cardiovascular risk. Learn who to screen and when, which measures to request, and how to stratify risk.",{"alt":316,"title":270,"size":317,"location":319},"Lipid panel blood sample tubes used to test for hyperlipidemia in a laboratory setting",{"width":318,"height":318},600,{"bucket":274,"key":320},"\u002F2026-04\u002FC121_magazine image.png",{"id":277,"title":278,"relativeURL":279,"image":280,"professionLong":281,"profession":322,"weight":284},{"name":283},"\u002Fmagazine\u002Ftest-for-hyperlipidemia",246,"5m",{"created":327,"updated":328,"published":329},1777403036,1777572381,1777412421,{"seo":331,"og":333},{"title":332,"description":213},"Diabetes management—minimizing weight gain | Medmastery",{"title":332,"description":213,"image":334},{"alt":270,"title":270,"size":335,"location":338},{"width":336,"height":337},705,368,{"bucket":274,"key":339},"\u002Fmigrated-images\u002FScreen Shot 2018-11-15 at 10.51.19 am.png",{"id":341,"created":342,"updated":343,"published":342},273,1540412854,1655189586]